Phylogene news

Publication in International Journal of Cosmetic Science

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Our new publication which shows how LC-MS/MS proteomics can reveal in an untargeted way the modifications of the intracellular fibroblast collagen proteome induced by differential treatments.


Skinobs Focus on Hair care substantiation

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How to characterize microbiota metabolism on scalp


Our PUBLICATION in COSMETICOBS

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Our publication in Cosmeticobs about modes of action on skin and its microbiota using omics techniques


BIO Digital 2021

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PHYLOGENE will attend BIO Digital June 10-11 & 14-18, 2021 and One-on-One Partnering.
We would be pleased to share some time with you to talk about your projects on which we could be useful.


LAUNCHING OF THE "ALLIANCE PROMOTION MICROBIOTE"

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Phylogene is proud to be part of the "Alliance Promotion Microbiote”.

This initiative should gather major microbiome industry actors in efforts to put the microbiome at the heart of diagnostic and therapeutic strategies for better care.


OUR EVENTS

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Thank you for the time spent with us at BIOFIT 2020, Oncology virtual partnering meeting 2021, NUTREVENT 2021, we look forward to seeing you again next edition!

 


PUBLICATION IN HEMATOLOGY

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A new publication in hematology based on plasma samples analysed by nanoLC-MS/MS proteomics method of choice for biomarker generating

 


OUR POSTER AT IFSCC 2020 ABOUT HUMAN INNERVATED REBUILT EPIDERMIS AND PROTEOMICS

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Our proteomics and bioinformatics study with partners contributed to understand the structure and working of the new human innervated reconstituted epidermis in testing ingredients effects


OUR POSTER/7th MICROBIOME AND PROBIOTICS R&D AND BUSINESS COLLABORATION FORUM: EUROPE 30th Nov -1st Dec 2020

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We look forward to talking to you about omics and bioinformatics for active molecules, pharmabiotics, diets or nutritional ingredients mechanisms of action and discovery on microbiotas. See an example of our tools presented in our poster.

http://www.global-engage.com/event/microbiota/#agenda

 


PUBLICATION ON SKIN MICROBIOTA

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Our metagenomics publication on C acnes phylotypes

Our metagenomics publication on C acnes phylotypes


FUNCTIONAL METAPROTEOMICS

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Metaproteomics allows accessing to activated functions at the human, bacteria and fungi level, metagenomics does not. To have an idea, see the link


DIET EFFECTS ON MICROBIOTAS

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How to get a large view on the effects of a diet on a microbiota at functional and mode of action levels


OMICS IN COSMETICS

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Genomics, transcriptomics, proteomics and metabolomics possibilities for cosmetics substantiation.


NEW PUBLICATION

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Our new publication in skin aging with partners


WHITE PAPER: METAPROTEOMICS FOR MICROBIOTA FUNCTIONS

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Untargeted approach, the best way for microbiota mode of action understanding.


PHOSPHOPROTEOMICS

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Protein phosphorylation is a crucial mechanism in many cellular regulations and strongly involved in virtually all physiological and pathological processes such as signal transduction, cell proliferation, differentiation, apoptosis or metabolism. Signaling processes involving phosphorylation are often deregulated during pathology or stress.


METAPROTEOMICS OF OUR MICROBIOME

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METAPROTEOMICS OF OUR MICROBIOME: The evolution of LC-MS/MS allows the  investigation of proteins in our saliva or skin or gut microbiome


COSMETOLOGY

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COSMETOLOGY : A new study in mice on UVB effects on mouse skin. Our experience is different on human skin therefore it remains important to stay in untargeted mode to be sure to keep the whole effects on pathways rather than defining variable biomarkers.


COSMETOLOGY

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COSMETOLOGY: Substantiation tests by  comparison of proteome of fibroblasts, keratinocytes, skin explants, rebuilt skin, D-squame, skin swabs, extra-cellular matrix.. Please contact us for these services.


PHYLOGENE-mass spectrometry

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PHYLOGENE-mass spectrometry has been granted by EUROSTARS for its NOSO-FIGHT project about Healthcare-Associated Infections.

PHYLOGENE-mass spectrometry is involved to the ID-THON project about tuna species identification

PHYLOGENE-mass spectrometry is partner of KINDReD, a FP7-Health-2013 Innovation project. The project is a 36 months and 14 partners project. Project aim is to develop drug candidate against kinetoplastids. PHYLOGENE- mass spectrometry is WP leader for drug's target determination.

PHYLOGENE will attend EIC 2013 on September 25th and 26th in Montpellier


XXIXth JED 2019

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XXIXth JED 2019 in Lyon Jan 31 - Feb 1st Presentation of our substantiation tools


HolXplore

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HolXplore: A new data processing module for host+microbiota outputs of omics comparison studies.


Functional microbiome

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Functional microbiome: How to understand the interactions between host and microbiota through functions .


SKIN MICROBIOME

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SKIN MICROBIOME: Metagenomics and proteomics to characterize products effects


DIABETES

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DIABETES: Understanding the diabetic nephropathy by label-free LC-MS/MS.


RedOxMics

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RedOxMics: Evaluation of the abiotic stress of the skin and oxidation deepness.


Toxicity

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Toxicity: Untargeted proteomics allows discovering positive effects and negative effects as well.


Post translational modifications

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Post translational modifications: PTMs, an essential mechanism of protein functionality


STRESS RESISTANCE AND CROP PRODUCTIVITY

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STRESS RESISTANCE AND CROP PRODUCTIVITY: A review on advances in plant proteomics. Many LC-MS//MS proteomics tools are now efficient, also available at MS-PHYLOGENE


LC-MS/MS MRM METHOD or ELISA

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LC-MS/MS MRM METHOD or ELISA? Do you know a multiplex LC-MS/MS MRM method can interestingly replace 20 ELISA methods at the development cost of 1 ELISA method?

Phylogene will be at Bio-Spring Europe in Paris , March 19-21, 2015


Nutrition

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Nutrition: Studying the effects of a diet on muscle metabolism


Microbiome

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Microbiome: Example with our tools of proteomics able to track simultaneously effects on host and microbiome


Probiotics

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Probiotics: Multi-omics for probiotics studies and metaproteomics for mechanisms of action understanding.


Fermentation

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Fermentation: Understanding the yeast or bacteria fermentation process with LC-MS/MS proteomics


OPHTALMOLOGY

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OPHTALMOLOGY: A study showed in 2011 the interest of tears to find biomarkers by LC/MS/MS for glaucoma; This new study shows that serum contains interesting proteins as biomarkers for uveitis which were found by label-free nanLC-MS/MS and which can be followed by MRM methods


RESISTANCE TO ANTIBIOTICS

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RESISTANCE TO ANTIBIOTICS:       MS-PHYLOGENE is now using its PROTABIORES database to characterize antibiotic resistance mechanisms. This LC-MS/MS peptide and protein database contains 53000 entries in September 2015


Plant metabolism

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Plant metabolism: Proteomics and phosphoproteomics to study the effects of environment.


Probiotics

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Probiotics: Proteomics and bioinformatics to understand the interactions between Lactobacilli and their environment.


Plant metaproteomics

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Plant metaproteomics: Functional stability while taxonomic strong variability on phyllosphere.


Cancer

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Cancer: Proteomics in early-phase drug development and clinical trials for new biomarkers


COSMETOLOGY NEWS

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COSMETOLOGY NEWS: UV effects, skin disorders through fibroblasts proteomes, skin microbiome by Highres proteomics.


WOUND HEALING AND TISSUE REGENERATION

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WOUND HEALING AND TISSUE REGENERATION: Proteins of interest by label-free LC-MS/MS


CORAVALID

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CORAVALID performs a complementary analysis of identification and quantification data through a series of statistics tests. It allows exploiting all the wealth of your LC-MS/MS data.


Substantiation

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Substantiation: An efficient innovative method


Understanding antimicrobial peptides mode of action

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Understanding antimicrobial peptides mode of action: The ectodermal dysplasia skin secretome comparison vs controls by nanoLC-MS/MS proteomics gives a more complete understanding of the pathology


DERMATOLOGY AND BIOMARKERS

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DERMATOLOGY AND BIOMARKERS: A study starting with untargetd relative quantification of psoriatic skins proteins to get a first set of 47 moving proteins followed by MRM targeted method of these proteins. Then 8 proteins were selected for further validation. A kind of routine?


FFPE and CANCER

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FFPE and CANCER: NanoLC-MS/MS proteomics uses small parts of available slices to produce biomarkers or find targets


Interactions between microbiome and host

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Interactions between microbiome and host: metaproteomics is the tool able to see both simultaneously


Publication

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Publication: Prediction of the effects of an ingredient using our proteomics and bioinformatics approach.


Therapeutic antibodies

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Therapeutic antibodies: Host Cell Proteins (HCP) characterization by nanoLC-MS/MS


Publication

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Publication: Photodamage on stratum corneum investigated with proteomics


PLANT IMPROVEMENT

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PLANT IMPROVEMENT: Proteomics and metabolomics are now mature


NEUROLOGICAL DISEASES

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LC-MS/MS proteomics approach of Alzheimer disesase.


COSMETOLOGY

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COSMETOLOGY: Oxidations follow-up by UVs


Analytical alternatives for allergen detection

Allergens

Analytical alternatives for allergen detection

 

ALLERGENS IN WINE: Regulation n°CE 579/2012

The regulation n° 579/2012 was published on June 30th 2012. The labelling of milk or egg is now mandatory on 2012 wines when using these fining agents. Its "whereas" n° (3) goes to the OIV-COMEX 502-2012 resolution which gives the 0,25ppm detection threshold. It means that the labelling is not necessary under this detected quantity .

PHYLOGENE - allergen specialized lab- tested all the available techniques for allergen tracking in wines. Many differences were seen between the ELISA kits about the false positive and false negative results (see study). To discard these risks and secure the bottle labelling it is necessary to check these two points when starting the analysis.


Identification and quantification of microbes

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Probiotics, process strains by RT-PCR


Accreditation extension for food allergens

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Since January 2013, PHYLOGENE is accreditated by COFRAC in flexible scope, according to  ISO 17025 standard, for allergens detection and quantification in food matrices by immunoenzymatic methods (ELISA) Ref Accreditation n°1-2128-testing- Scope available on www.cofrac.fr


Species identification

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Yes, PHYLOGENE realizes for 13 years species identification, terrestrial and fishes

Yes, this is targeted detection, the choice of species depends on your estimated risk.

Yes, the quantification is possible. It is of the type: horse/horse+beef


Skin microbiota

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Metagenomics recent developments now enable the skin microbiome investigation. PHYLOGENE offers bacterial 16s rDNA and fungal ITS sequencing with OTU-based approaches to investigate microbial communities diversity and determine taxonomic composition for cosmetics evaluation

(see also LC-MS/MS proteomics for metaproteomics)


Cosmetic 360 in Paris

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Cosmetic 360 in Paris: A lot of interest of our combined genomic and proteomic approach of skin and microbiome.


CANCER

 

CANCER: A study of phosphoproteins and signaling networks in bioological cell lines and tissues allows understanding induced effects by cancer and also drug resistance


Bioinformatics

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CORAVALID

LC-MS/MS output data are rich but often large and complex to be treated. So it takes a lot of time to our customers.


STEM CELLS

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STEM CELLS: Mechanisms and biomarkers of differentiation by HR proteomics.


BIOMARKER AND DISCOVERY WORKFLOW

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BIOMARKER AND DISCOVERY WORKFLOW: our poster at EBF 2015


RESISTANCE TO ANTIBIOTICS

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RESISTANCE TO ANTIBIOTICS: Impact of rapid diagnostics on antibiotic misuse.


Our posters at IFSCC2018

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Our posters at IFSCC2018: "Hypothesis free" proteomics and its dedicated bioinformatics efficient for studying the corneome and ceramidome of photodamaged SC, the secretome of fibroblasts, and effects of Prunus enzymatic extracts on skin explants.


Phylogene and Dermatec collaboration on skin microbiome

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Phylogene and Dermatec collaboration on skin microbiome:
Based on its well established cohorts of volunteers and its qualified teams, Dermatec designs and realizes clinical trials in dermo-cosmetics with necessary specific biological samples dedicated to skin microbiome study.
On these samples, Phylogene does genomics and/or proteomics testing and associated bioinformatics /biostatistics data processing which highlight the effects on skin and its microbiome.
A good solution for your microbiome studies!


CRISPR-Cas9 modifications checking

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CRISPR-Cas9 modifications checking: LC-MS/MS proteomics is a good tool for specific and unspecific modifications as well.


SUNFLOWER

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Leaf heterosis in label-free proteomics.


CANCEROLOGY

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CANCEROLOGY: Kinome and kinases inhibitors by LC-MS/MS. Please contact us for these evaluations.


INFECTIOUS DISEASES

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INFECTIOUS DISEASES: The infectious process of Dengue virus followed by HighRes proteomics. Please contact us for these tests.


JOURNEES JP MARTY

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JOURNEES JP MARTY: PEAU ET MICRORGANISMES 8-9 Dec 2015. This nice meeting updated us on skin microbiome


SID 2016

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SID 2016 (Society for Investigative Dermatology): Our poster on the UVs effects on stratum corneum determined by highres quantitative LC-MS/MS proteomics


AIS 2017

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AIS 2017: ADCs event: our poster


Our poster at ESDR2017

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Our poster at ESDR2017: The possibilities of proteomics to study skin and its microbiome simultaneously at the functional level.


VACCINES

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VACCINES: The Outer Membrane Vesicles as a source of vaccine antigens.


CANCEROLOGY

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CANCEROLOGY: An example of biopsy comparison.


New nanoLC-MS/MS

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New nanoLC-MS/MS: MS Phylogene received this end of 2016 a nanoLC U3000 Dionex coupled to a Q-Exactive PLUS HCD Thermo for the best performances in proteomics and metabolomics.


Synergy meeting in Modena

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Synergy meeting in Modena on Drug Development for Neglected Parasitic Diseases FP7 funded projects where Kindred project is one of the 4 projects: Our poster on kinases and kinases inhibition profiling.


IFSCC 2016

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IFSCC 2016: Our poster on MS proteomics of dry  skin in different ethnic groups has been awarded as one of the top 10 out of 313. It shows the power of the method in revealing new involved pathways.


PROBIOTICS

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The comparison of Bifidobacterium strains by label-free LC-MS/MS allows their differentiation in the process.

During Cosmetic days 2014 meeting, PHYLOGENE presented a poster: "High-resolution nano LC-MS/MS proteomics and CORAVALID data processing: For a new approach of substantiation tests "